A fluorinated benzoic acid building block
Used as a synthesis intermediate for APIs
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2-Fluoro-6-methylbenzoic acid (CAS number 90259-27-1) is an ortho-benzoic acid with both methyl and fluoride substituents sitting at ortho-positions to the carboxylic acid. 2-Fluoro-6-methylbenzoic acid is involved in the synthesis of epidermal growth factor receptor (EGFR) inhibitor with potency of 340 nM. In the synthesis of the EGFR inhibitor, the methyl group of 2-fluoro-6-methylbenzoic acid undergoes radical bromination, enabling nucleophilic substitution to phthalimide. Subsequently, the carboxylic acid group is attached to the allosteric motif through an amination reaction to form the inhibitor.
2-Fluoro-6-methylbenzoic acid is also a key building block of avacopan which is used to treat anti-neutrophil cytoplasmic autoantibody-associated vasculitis.
Multiple functional groups
For facile synthesis
Fluorinated benzoic acid building block
For drug discovery, medicinal chemistry, and biochemistry
Low Cost
Competitively priced, high quality product
High purity
>97% High purity
General Information
| CAS Number | 90259-27-1 |
| Chemical Formula | C8H7FO2 |
| Full Name | 2-Fluoro-6-methylbenzoic acid |
| Molecular Weight | 154.14 g/mol |
| Synonyms | 2-Carboxy-3-fluorotoluene, 6-Fluoro-o-toluic acid |
| Classification / Family | Fluorinated building blocks, Benzoic acid building blocks, APIs |
Chemical Structure
Product Details
| Purity | 97% |
| Melting Point | Tm = 124 °C – 125 °C |
| Appearance | White Powder |
MSDS Documentation
Literature and Reviews
- Avacopan. C5a anaphylatoxin chemotactic receptor 1 (C5aR1) antagonist, Treatment of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis, J. Pease, Drugs of the Future, 46 (3), 183–190 (2021); DOI: 10.1358/dof.2021.46.3.3239643.
- Discovery of potent and selective PI3Kγ inhibitors, S. Drew et al., J. Med. Chem., 63, 11235–11257 (2020); DOI: 10.1021/acs.jmedchem.0c01203.
- Discovery of 3‑cyano‑N‑(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)‑1H‑pyrrolo[2,3‑b]pyridin-5-yl)benzamide: a potent, selective, and orally bioavailable retinoic acid receptor-related orphan receptor C2 inverse agonist, M. Schnute et al., J. Med. Chem., 61, 10415–10439 (2018); DOI: 10.1021/acs.jmedchem.8b00392.
