Cart(0)
Unleash Creativity with Adult Building Blocks – Models, Figurines, and Accessories
Unleash Creativity with Adult Building Blocks – Models, Figurines, and Accessories Unleash Creativity with Adult Building Blocks – Models, Figurines, and Accessories
Home Adult Building Block Toys Animal Series Building Blocks
2-Fluoropyridine-3-carbonitrile
2-Fluoropyridine-3-carbonitrile
Quantity:
  • 10g
  • 25g
  • 50g

$ 0.00

$ 90.00

Please select combo product attributes
The combo subtotal is $,SAVE$

Product Details

A fluorinated nicotinonitrile building block

Used for the synthesis of bicyclic heterocycles in medicinal chemistry


| |


2-Fluoropyridine-3-carbonitrile (CAS number 3939-13-7), also named as 2-fluoronicotinonitrile, is a nicotinonitrile building block featuring a fluoride substituent at 2-position. 2-Fluoropyridine-3-carbonitrile commonly serves as a synthesis precursor for active pharmaceutical ingredients (APIs), such as niflumic acid that is used for joint and muscular pain relief. Pyrazopyridine, a bicyclic heterocycle can be synthesised from 2-fluoropyridine-3-carbonitrile. The reaction begins with a nucleophilic aromatic substitution of hydrazine, followed by a pyrazole cyclisation reaction.

Additionally, 2-fluoropyridine-3-carbonitrile can be modified through Minisci reaction for meta- and para-alkylation.

Multiple functional groups

For facile synthesis

Fluorinated hydroxybenzoic acid building block

For drug discovery, medicinal chemistry and biochemistry research

Worldwide shipping

Quick and reliable shipping

High purity

>98% High purity

General Information


CAS Number 3939-13-7
Chemical Formula C6H3FN2
Full Name 2-Fluoronicotinonitrile
Molecular Weight 122.10 g/mol
Synonyms 3-Cyano-2-fluoropyridine
Classification / Family Fluorinated building blocks, Heterocyclic building blocks, Nicotinonitrile building blocks, APIs

Chemical Structure


2-Fluoropyridine-3-carbonitrile chemical structure, CAS 3939-13-7

Product Details


Purity 98%
Melting Point Tm = 28 °C – 33 °C
Appearance White crystals

MSDS Documentation


Literature and Reviews


  1. Antiproliferative activity of some newly synthesized substituted pyridine candidates using 4‑(aryl)-6-(naphthalen-1-yl)-2-oxo-1,2-dihydropyridine-3-carbonitrile as synthon, A. El-Sayed et al., ACS Omega, 6, 7147–7156(2021); DOI: 10.1021/acsomega.1c00202.
  2. Second-generation CD73 inhibitors based on a 4,6-biaryl-2-thiophyridine scaffold, R. Ghoteimi et al., ChemMedChem, 18, e202200594(2023); DOI: 10.1002/cmdc.202200594.
  3. New reactions of 5-amino-3-(cyanomethyl)-1H-pyrazole-4-carbonitrile, V. Dotsenko et al., Chem. Proc., 3, 23(2023); DOI: 10.3390/ecsoc-24-08398.

You May Also Like
Unavailable
Cart
Unleash Creativity with Adult Building Blocks – Models, Figurines, and Accessories
Your cart is currently empty.