A fluorinated benzoic acid building block
For applications as an intermediate in the preparation of APIs giving treatment of Alzheimer's disease.
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3-Fluoro-4-methoxybenzoic acid (CAS number 403-20-3) is a fluorinated para-anisic acid derivative. The fluoride substituent enables nucleophilic aromatic substitution, while most of the reactivity centred on the carboxylic group. 3-Fluoro-4-methoxybenzoic acid can undergo various reactions, including Fischer esterification affording esters with ligustrazine moiety for the treatment of Alzheimer's disease.
Furthermore, 3-Fluoro-4-methoxybenzoic acid can be transformed into benzoyl chloride using thionyl chloride to enhance its reactivity, thereby providing a platform for Friedel-Craft acylation reaction. Additionally, 3-Fluoro-4-methoxybenzoic acid can be modified into hydrazide which is used in the synthesis of oxadiazoles for antimicrobial applications.
Multiple functional groups
For facile synthesis
Fluorinated benzoic acid building block
for drug discovery, medicinal chemistry and biochemistry research
Worldwide shipping
Quick and reliable shipping
High purity
>98% High purity
General Information
| CAS Number | 403-20-3 |
| Chemical Formula | C8H7FO3 |
| Full Name | 3-Fluoro-4-methoxybenzoic acid |
| Molecular Weight | 170.14 g/mol |
| Synonyms | 3-Fluoro-p-anisic Acid |
| Classification / Family | Fluorinated building blocks, Benzoic acid building blocks, Anisic acid building blocks, APIs |
Chemical Structure
Product Details
| Purity | 98% |
| Melting Point | Tm = 211 °C – 213 °C |
| Appearance | White powder |
MSDS Documentation
Literature and Reviews
- 3,5-Dialkoxypyridine analogues of bedaquiline are potent antituberculosis agents with minimal inhibition of the hERG channel, H. Sutherland et al., Bioorg. Med. Chem., 27, 1292–1307(2019); DOI: 10.1016/j.bmc.2019.02.026.
- Studies on dibenzylamines as inhibitors of Venezuelan Euinine encephalitis virus, T. Nguyen et al., ACS Infect. Dis., 5(12), 2014–2028(2019); DOI: 10.1021/acsinfecdis.9b00035.
- Synthesis, characterization, and pharmacological screening of new 1,3,4-oxadiazole derivatives possessing 3-fluoro-4-methoxyphenyl moiety, Shivapura et al., Monatsh. Chem., 146, 207–214(2015); DOI: 10.1007/s00706-014-1291-9.
