Name: 4-Fluoro-1,2-phenylenediamine
SKU: 67794

A fluorinated o-phenylenediamine building block

For the synthesis of Schiff bases in applications of APIs and batteries

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4-Fluoro-1,2-phenylenediamine (CAS number 367-31-7) is a fluorinated ortho-phenylenediamine. 4-Fluoro-1,2-phenylenediamine serves as a hardener for epoxy resins to enhance their thermal conductivity, thereby improving the thermal management of electrical motors and integrated circuits. The ortho-positioning of the amine groups enables 4-fluoro-1,2-phenylenediamine to form salen-type Schiff bases with salicylaldehydes. Such Schiff bases can coordinate to Co, Ni, Cu and Zn, affording corresponding organometallic complexes. The salen-type Schiff bases metal complexes show multiple applications, such as antimicrobial agents and redox carriers for flow batteries.

4-Fluoro-1,2-phenylenediamine is also utilized in the synthesis of 2,3-diaminophenazines through an oxidative reaction. 2,3-diaminophenazines have a wide range of applications in dyes and drug discovery.

Multiple functional groups

For facile synthesis

Fluorinated o-phenylenediamine building block

For drug discovery, Schiff bases, and battery research

Low Cost

Competitively priced, high quality product

High purity

>97% High purity

General Information

CAS Number	367-31-7
Chemical Formula	C₆H₇FN₂
Full Name	4-Fluoro-1,2-benzenediamine
Molecular Weight	126.13 g/mol
Synonyms	3,4-Diamino-1-fluorobenzene, 2-Amino-4-fluoroaniline, 4-Fluoro-o-phenylenediamine
Classification / Family	Fluorinated building blocks, Phenylenediamine building blocks, Ligands, Schiff bases, Batteries, APIs

Chemical Structure

4-Fluoro-1,2-phenylenediamine chemical structure, CAS 367-31-7

Product Details

Purity	97%
Melting Point	T_m = 94 °C – 98 °C
Appearance	Brown powder

MSDS Documentation

Literature and Reviews

Fluorinated 2,3-diaminophenazines: synthesis, mechanism of formation, and properties, J. Li et al., New J. Chem., 47, 19556–19568 (2023); DOI: 10.1039/D3NJ02875E.
GreenMedChem: the challenge in the next decade toward eco-friendly compounds and processes in drug design, C. Castiello et al., Green Chem., 25, 2109 (2023); DOI: 10.1039/d2gc03772f.
Effect of amine hardener molecular structure on the thermal conductivity of epoxy resins, G. Lv et al., ACS Appl. Polym. Mater., 3, 259–267 (2021); DOI: 10.1021/acsapm.0c01074.

Expanding the potential of redox carriers for flow battery applications, A. Gabriel et al., J. Mater. Chem. A, 8, 17808–17816 (2020); DOI: 10.1039/D0TA04511J.
Investigation on Co(II), Ni(II), Cu(II) and Zn(II) complexes derived from quadridentate salen-type Schiff base: structural characterization, DNA interactions, antioxidant proficiency and biological evaluation, G. Ramesh et al., Chem. Data Coll., 28, 100434 (2020); DOI: 10.1016/j.cdc.2020.100434.