A fluorinated chiral heterocyclic building block
Used as a synthesis intermediate for active pharmaceutical ingredients (APIs) and polymer in lithium solid-state batteries
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(5S)-(−)-5-(Trifluoromethyl)-2-pyrrolidinone (CAS number 1287211-10-2), a derivative of the well known 2-pyrrolidinone, is a five-membered lactam (γ-lactam) with a trifluoromethyl substituent on a S-chiral carbon centre (left-handed). Many derivatives of 2-pyrrolidinone are bioactive including cotinine (antidepressant), doxapram (respirator stimulant) and seletracetam (anticonvulsant). (5S)-(−)-5-(Trifluoromethyl)-2-pyrrolidinone has a high potential for using in APIs development, due to the lipophilicity from trifluoromethyl group. The chiral centre is also preferred for systematic studies in medicinal chemistry.
Polyvinylpyrrolidone (PVP) is popularly used in development of solid-state batteries, as a binder maintaining cohesion for intercalation type cathodes. PVP is easily prepared through a radical polymerisation, while its monomer vinylpyrrolidone can be obtained from pyrrolidinone and acetylene.
Multiple functional groups
For facile synthesis
Worldwide shipping
Quick and reliable shipping
Fluorinated chiral pyrrolidone building block
For drug discoveries, organic synthesis, and batteries
High purity
>97% High purity
General Information
| CAS Number | 1287211-10-2 |
| Chemical Formula | C5H6F3NO |
| Full Name | (5S)-5-(Trifluoromethyl)pyrrolidin-2-one |
| Molecular Weight | 153.10 g/mol |
| Synonyms | N/A |
| Classification / Family | Pyrrolidinone derivatives, Heterocyclic building block, Fluorinated building block, API synthesis intermediates, Batteries |
Chemical Structure
Product Details
| Purity | >97% |
| Boiling Point | Tm = 98 °C – 105 °C |
| Appearance | White powder/crystal |
MSDS Documentation
Literature and Reviews
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An overview on chemistry and biologcal importance of pyrrolidinone, Z. Hosseinzadeh et al., Curr. Org. Chem., 14, 1-13(2017);DOI: 10.2174/1570179414666170908165445.
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Inks for Li-ion battery anodes printed by rotogravure, J. Mateo et al., Advances in Printing and Media Technology, 47(8), 171-176(2022); DOI: 10.14622/Advances_48_2022_04
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PVP-assisted synthesis of ultrafine transition metal oxides encapsulated in nitrogen-doped carbon nanofibers as robust and flexible anodes for sodium-ion batteries, Q. Zhao et al, Carbon, 174, 325-334(2021); DOI:10.1016/j.carbon.2020.12.016.
