A fluorinated nicotinic acid building block
Used as a bioactive molecule for medicinal chemistry research
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6-Fluoronicotinic acid (CAS number 403-45-2), also recognized as niacin, is a fluorinated nicotinic acid. 6-Fluoronicotinic acid is a derivative of pyridine, with a carboxylic acid at 3-position and a fluorine at 6-position. Nicotinic acid is an important food supplement and used to treat pellagra, a vitamin B3 deficiency disease. 6-Fluoronicotinic acid is applied as a molecular scaffold to synthesize tracers for positron emission tomography, for visualizing and measuring changes in metabolic processes.
Being bioactive, 6-fluoronicotinic acid is commonly used as a building block for active pharmaceutical ingredients (APIs). A derivative of quinoline-8-yl-nicotinamide synthesised from 6-fluoronicotinic acid is investigated for pancreatic cancer treatment.
Multiple functional groups
For facile synthesis
Fluorinated carboxylic acid building block
For drug discovery, medicinal chemistry and biochemistry research
Worldwide shipping
Quick and reliable shipping
High purity
>98% High purity
General Information
| CAS Number | 403-45-2 |
| Chemical Formula | C6H4FNO2 |
| Full Name | 2-Fluoro-5-pyridinecarboxylic acid |
| Molecular Weight | 141.10 g/mol |
| Synonyms | 6-Fluoropyridine-3-carboxylic acid |
| Classification / Family | Fluorinated building blocks, Heterocyclic building blocks, APIs, Ligands |
Chemical Structure
Product Details
| Purity | 98% |
| Melting Point | Tm = 144 – 148°C |
| Appearance | White powder |
MSDS Documentation
Literature and Reviews
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Early detection and longitudinal monitoring of experimental primary and disseminated melanoma using [18F]ICF01006, a highly promising melanoma PET tracer, L. Rbah-Vidal et al., Eur. J. Nucl. Med. Mol. Imaging, 39, 1449–1461(2012); DOI: 10.1007/s00259-012-2168-y.
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Fast indirect fluorine-18 labelling of protein/peptide using the useful 6-fluoronicotinic acid-2,3,5,6-tetrafluorophenyl prosthetic group: a method comparable to direct fluorination, F. Basuli et al., J. Labelled Comp. Radiopharm., 60(3), 168–175(2017); DOI: 10.1002/jlcr.3487.
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Induction of genes implicated in stress response and autophagy by a novel quinolin-8-yl-nicotinamide QN532 in pancreatic cancer, Y. Kuang et al., J. Med. Chem., 65(8), 6133–6156(2022); DOI: 10.1021/acs.jmedchem.1c02207.
